Human DMPK Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB6967V Datasheet / COA / SDS

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FAB6967V-100UG

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Human DMPK Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human DMPK in direct ELISAs.

Source

Monoclonal Mouse IgG2b Clone # 713931

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human DMPK
Glu393-Thr543
Accession # Q09013

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DMPK

DMPK (dystrophia myotonica protein kinase), also called DMK, MDPK or MT-PK (myotonin protein kinase) is an 80 kDa cytoplasmic protein of the ser/thr kinase superfamily (EC 2.7.11.1). The 639 amino acid (aa) human DMPK includes a protein kinase domain (aa 81-349), an AGC kinase C-terminal domain (aa 350-425) and a coiled-coil negative regulatory domain that mediates dimerization (aa 467-546). Within the region used as an immunogen, human DMPK shares 72% and 73% aa sequence identity with mouse and rat DMPK, respectively. This region is included within 12 isoforms that range in size from 530-634 aa. The most prominent, muscle-specific isoform phosphorylates phospholamban and is critical for cardiac contractility.

Long Name

Dystrophia Myotonica Protein Kinase

Entrez Gene IDs

1760 (Human); 13400 (Mouse); 308405 (Rat)

Alternate Names

DM1; DM1PK; DMK; DMKEC 2.7.11.1; DM-kinase; DMmyotonin protein kinase A; DMPK; dystrophia myotonica-protein kinase; MDPK; MDPKDM protein kinase; MT-PK; MT-PKmyotonic dystrophy associated protein kinase; Myotonic dystrophy protein kinase; myotonin-protein kinase; thymopoietin homolog