Endomucin (Endothelial sialomucin; also MUC-14, Endomucin-2 and Ga34) is an 85-115 kDa glycoprotein that belongs to no known family of molecules. It is expressed by primitive bone marrow stem cells, endothelial cells of both blood and lymphatic vessels, and select keratinocytes. Endomucin appears to create an environment that discourages leukocyte binding to vascular walls, and yet may also serve as an L-Selectin ligand. Mature human Endomucin is a 243 amino acid (aa) type I transmembrane glycoprotein (aa 19-261). It contains a 172 aa extracellular domain (ECD) (aa 19-190) plus a 50 aa cytoplasmic tail (aa 212-261). The ECD possesses a uteroglobin-like domain (aa 19-74) plus multiple sites for N- and O-linked glycosylation. There are potential splice variants that seem to parallel those in mouse. One shows a deletion of aa 140-222 and is likely soluble, while another possesses a Ser substitution for aa 126-139. Over aa 19-139, human Endomucin shares only 35% aa identity with mouse Endomucin.
Human Endomucin Alexa Fluor® 594‑conjugated Antibody
R&D Systems | Catalog # AF7206T
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Immunogen
Asn19-Gly139
Accession # Q9ULC0
Specificity
Clonality
Host
Isotype
Applications for Human Endomucin Alexa Fluor® 594‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Purification
Formulation
Shipping
Stability & Storage
Background: Endomucin
Alternate Names
Gene Symbol
UniProt
Additional Endomucin Products
Product Documents for Human Endomucin Alexa Fluor® 594‑conjugated Antibody
Certificate of Analysis
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Product Specific Notices for Human Endomucin Alexa Fluor® 594‑conjugated Antibody
This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.
For research use only
Related Research Areas
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Protocols
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