FACA (Fanconi anemia group A) is a 160‑165 kDa protein that belongs to Fanconi anemia protein group I. FACA is widely expressed, activated by phosphorylation, partners with FANCG, and participates in the formation of an eight subunit Fanconi anemia core complex that ubiquitinates FANCD2 and FANCI. Ultimately, this contributes to the reactivation of stalled DNA repair replication forks. Human FACA is 1455 amino acids (aa) in length. It contains one NLS (aa 18‑34) and four phosphorylation sites at Ser849, 850, 858 and 1449. There are four potential splice variants. One shows a premature truncation after Cys297, a second contains a six aa substitution for aa 297‑1455, a third shows a deletion of aa 143‑174 accompanied by truncation after Cys297, and a fourth exhibits an alternative start site at Met528, accompanied by a 35 aa substitution for aa 1390‑1455. Over aa 35‑142, human FACA shares 61% aa identity with mouse FACA.
Human FACA/FANCA Alexa Fluor™ Plus 680‑conjugated Antibody
R&D Systems | Catalog # AF6026AFP680
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Antibody Source
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Applications for Human FACA/FANCA Alexa Fluor™ Plus 680‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
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Background: FACA/FANCA
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Product Documents for Human FACA/FANCA Alexa Fluor™ Plus 680‑conjugated Antibody
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Product Specific Notices for Human FACA/FANCA Alexa Fluor™ Plus 680‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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