Fc gamma RIIIB/CD16b is a low/intermediate affinity receptor for polyvalent immune-complexed IgG. It is a GPI-anchored protein that is selectively expressed on the surface of neutrophils and eosinophils. Fc gamma RIIIB functions as a decoy receptor that binds IgG complexes without triggering activation. A shed soluble form of Fc gamma RIIIB can interact with complement receptors CR3 and CR4 on monocytes to induce the production of pro-inflammatory cytokines.
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