Human FCRL2/FcRH2 PE-conjugated Antibody

Clone 296902 was used by HLDA to establish CD designation.
  • Species Reactivity
  • Specificity
    Detects human FCRL2/FcRH2 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) FCRL1, 3, 4, or 5 is observed.
  • Source
    Monoclonal Mouse IgG1 Clone # 296902
  • Purification
    Protein A or G purified from hybridoma culture supernatant
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human FCRL2/FcRH2
    Accession # Q96LA5
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
  • Flow Cytometry
    10 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Examples
Detection of FCRL2/FcRH2 in CD19+ Human Lymphocytes by Flow Cytometry. CD19+ human lymphocytes were stained with Mouse Anti-Human FCRL2/FcRH2 PE‑conjugated Monoclonal Antibody (Catalog # FAB2048P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: FCRL2/FcRH2

Fc receptor-like 2 (FCRL2), also known as FcRH2 and IRTA4, belongs to the family of glycoprotein homologs of classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembrane FCRL protein family contains from three to nine immunoglobulin-like domains (1, 2). Mature human FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) with four Ig-like C2-set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmic domain with one ITAM-like, and two ITIM-like motifs (3‑5). Alternate splicing of human FCRL2 may generate isoforms with N-terminal, internal, or C-terminal deletions (4, 5). The gene for FcRH2 maps to the human Iq21-23 locus which is a hotspot for chromosomal translocation events associated with B cell malignancies (3, 6). Although there are several Fc receptor-like genes in the mouse, none of these is a clear ortholog to human FCRL2 (7). FCRL proteins are differentially expressed among B cells (2). FCRL2 is preferentially expressed on naïve and CD27+ memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood (3, 4, 8, 9). It is also expressed on most B cells in B cell chronic lymphocytic leukemia (B-CLL) patients (10). FCRL2 upregulation is associated with mutation of the immunoglobulin heavy chain variable (IGHV) and less aggressive forms of B-CLL (9, 11).


  • References:
    1. Maltais, L.J. et al. (2006) Nat. Immunol. 7:431.
    2. Davis, R.S. et al. (2007) Annu. Rev. Immunol. 25:525.
    3. Miller, I. et al. (2002) Blood 99:2662.
    4. Davis, R.S. et al. (2001) Proc. Natl. Acad. Sci. 98:9772.
    5. Xu, M.J. et al. (2001) Biochem. Biophys. Res. Commun. 280:768.
    6. Hatzivassiliou, G. et al. (2001) Immunity 14:277.
    7. Davis, R.S. et al. (2004) Int. Immunol. 16:1343.
    8. Polson, A.G. et al. (2006) Int. Immunol. 18:1363.
    9. Huttmann, A. et al. (2006) Leukemia 20:1774.
    10. Kazemi, T. et al. (2008) Int. J. Cancer 123:2113.
    11. Li, F.J. et al. (2008) Blood 112:179.
  • Long Name:
    Fc Receptor-like 2
  • Entrez Gene IDs:
    79368 (Human)
  • Alternate Names:
    CD307b antigen; CD307b; Fc receptor homolog 2; Fc receptor-like 2; FcRH2; FCRH2SPAP1B; FcRL2; FcR-like protein 2; IFGP family protein 4; IFGP4; Immunoglobulin receptor translocation-associated protein 4; immunoglobulin superfamily Fc receptor, gp42; IRTA4; IRTA4SPAP1C; SH2 domain containing phosphatase anchor protein 1; SH2 domain-containing phosphatase anchor protein 1Fc receptor-like protein 2; SPAP1; SPAP1A; SPAP1immune receptor translocation-associated protein 4
Related Research Areas
Isotype Controls
Description Application Cat# Citations Images  

Mouse IgG1 PE-conjugated Antibody

Ctrl IC002P 28  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 3
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 1
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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