Human GAT-1/SLC6A1 (NP_003033) VersaClone cDNA

R&D Systems | Catalog # RDC1033

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Key Product Details

Species

Human

Accession Number

NP_003033

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: GAT-1/SLC6A1

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl negative channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-1, the most abundant of the transporters, is found predominantly in neurons, but also in some specialized glia (Minelli et al., 1995). GAT-1 is thought to play a key role in epileptogenesis (Zhao et al. 2003).

Long Name

GABA Transporter 1

Alternate Names

GABATHG, GABATR, GAT1, SLC6A1

Entrez Gene IDs

6529 (Human); 232333 (Mouse); 79212 (Rat)

Gene Symbol

SLC6A1

UniProt

NP_003033

Additional GAT-1/SLC6A1 Products

Product Documents for Human GAT-1/SLC6A1 (NP_003033) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human GAT-1/SLC6A1 (NP_003033) VersaClone cDNA

For research use only

Citations for Human GAT-1/SLC6A1 (NP_003033) VersaClone cDNA

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