Potent and selective inhibitor of GABA uptake by GAT-1 (IC50
values are 0.04, 171, 1700 and 622 μ
M for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo
. Also exhibits cognition-enhancing activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization.
Suzdak et al.
Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor.
O'Connell et al.
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
Borden et al.
The citations listed below are publications that use Tocris products. Selected citations for NNC 711 include:
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