Chemical Name: 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride
Biological ActivityNNC 711 is a potent and selective inhibitor of GABA uptake by GAT-1 (IC50 values are 0.04, 171, 1700 and 622 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). Anticonvulsant following systemic administration in vivo. Also exhibits cognition-enhancing activity.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
Borden et al.
NNC-711, a novel potent and selective γ-aminobutyric acid uptake inhibitor: pharmacological characterization.
Suzdak et al.
Anti-ischemic and cognition-enhancing properties of NNC-711, a γ-aminobutyric acid reuptake inhibitor.
O'Connell et al.
Citations for NNC 711
The citations listed below are publications that use Tocris products. Selected citations for NNC 711 include:
4 Citations: Showing 1 - 4
A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.
Authors: Kersanté Et al.
Noisy galvanic vestibular stimulation promotes GABA release in the substantia nigra and improves locomotion in hemiparkinsonian rats.
Authors: Samoudi Et al.
PLoS One 2012;7:e29308
Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats.
Authors: Yoshizumi Et al.
Glutamate uptake triggers transporter-mediated GABA release from astrocytes.
Authors: Héja Et al.
J Physiol 2009;4:e7153
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