Human GluR3 Alexa Fluor™ Plus 488‑conjugated Antibody

R&D Systems | Catalog # FAB11329AFP488

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 488 (Excitation = 493 nm, Emission = 518 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1059821
View all GluR3 Primary Antibodies »

Product Specifications

Specificity

Detects human GluR3 in direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human GluR3 Alexa Fluor™ Plus 488‑conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: GluR3

GluR3 is a receptor for glutamate. Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiological processes. This gene belongs to a family of AMPA receptors.  GluR3 is a gene product of the GRIA3 gene and its pre-mRNA is subject to RNA editing. In humans, 80-90% of GRIA3 transcripts are edited. This allows sustained response to rapid stimuli. There is a tentative link between defective GRIA3 variants and a highly elevated risk of schizophrenia.

References

  1. Entrez Gene: GRIA3 glutamate receptor, ionotropic, AMPA 3.
  2. Seeburg PH, Higuchi M, Sprengel R. "RNA Editing of Brain Glutamate Receptor channels:  Mechanism and Physiology". Brain Res. Brain Res. Rev. 1998, May; 26(2-3):217.
  3. Lomeli H, Mosbacher J, Höger T, Geiner JR, Kuner T, Monyer H, Higuchi M, Bach A, Seeburg PH., "Control of Kinetic Properties of AMPA rREceptor Channels by Nuclear RNA Editing". Science. 1994, Dec; 266(5191):1709.

Long Name

Glutamate Receptor 3

Alternate Names

AMPA3, GLUR-K3, GLURC, GRIA3

Entrez Gene IDs

2892 (Human); 53623 (Mouse); 29628 (Rat)

Gene Symbol

GRIA3

UniProt

P42263 (Human)

Additional GluR3 Products

Product Documents for Human GluR3 Alexa Fluor™ Plus 488‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human GluR3 Alexa Fluor™ Plus 488‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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