Human Histone Deacetylase 5 (NP_005465.2) VersaClone cDNA

R&D Systems | Catalog # RDC3463

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Key Product Details

Species

Human

Accession Number

NP_005465.2

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Histone Deacetylase 5/HDAC5

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF(p300/CBP- associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6, have been identified as histone deacetylases.

Long Name

Histone Deacetylase 5

Alternate Names

FLJ90614, KIAA0600, NY-CO-9

Entrez Gene IDs

10014 (Human)

Gene Symbol

HDAC5

UniProt

NP_005465.2

Additional Histone Deacetylase 5/HDAC5 Products

Product Documents for Human Histone Deacetylase 5 (NP_005465.2) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human Histone Deacetylase 5 (NP_005465.2) VersaClone cDNA

For research use only

Related Research Areas

Adult Neurogenesis
Epigenetics

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