Human IL-11 R alpha (NP_001136256) VersaClone cDNA Summary
Background: IL-11 R alpha
IL-11 Ra (Interleukin-11 receptor alpha) is a widely expressed transmembrane protein that associates with gp130 to form a functional receptor complex for the cytokine IL-11. gp130 also functions as a subunit in the receptors for Cardiotrophin-1, CNTF, IL-6, IL-27, IL-31, LIF, and Oncostatin M. IL-11 Ra plays a role in female reproduction and the survival of oligodendrocytes and colonic epithelial cells. It enhances osteoclast differentiation and bone remodeling but inhibits adipocyte differentiation. Soluble IL-11 Ra confers IL-11 responsiveness to cells expressing gp130, while in cells expressing transmembrane IL-11 Ra and gp130, soluble IL-11 Ra acts as an IL-11 antagonist.
Citation for Human IL-11 R alpha (NP_001136256) VersaClone cDNA
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1 Citation: Showing 1 - 1
The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis
Authors: SF Stuart, A Bezawork-G, Z Areeb, J Gomez, V Tsui, A Zulkifli, L Paradiso, J Jones, HPT Nguyen, TL Putoczki, PV Licciardi, G Kannouraki, AP Morokoff, AA Achuthan, RB Luwor
International Journal of Molecular Sciences, 2023-02-08;24(4):. 2023-02-08
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