LILRB4, also known as ILT3, CD85k, and LIR-5, is a transmembrane glycoprotein that is expressed on dendritic cells (DC), monocytes, macrophages, and vascular endothelial cells (EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cell-activating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells (Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 upregulation and a tolerogenic phenotype in monocytes, DC, and EC.
Human LILRB4/CD85k/ILT3 (NP_001265355) VersaClone cDNA
R&D Systems | Catalog # RDC1178
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: LILRB4/CD85k/ILT3
Long Name
Leukocyte Immunoglobulin-like Receptor, Subfamily B (with TM and ITIM Domains), Member 4
Alternate Names
CD85k, HM18, ILT3, LIR5
Gene Symbol
LILRB4
UniProt
Additional LILRB4/CD85k/ILT3 Products
Product Documents for Human LILRB4/CD85k/ILT3 (NP_001265355) VersaClone cDNA
Product Specific Notices for Human LILRB4/CD85k/ILT3 (NP_001265355) VersaClone cDNA
For research use only
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