Human LILRB5/CD85c/LIR-8 Alexa Fluor™ Plus 647‑conjugated Antibody

R&D Systems | Catalog # FAB30651AFP647

R&D Systems

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

Alexa Fluor Plus 647 (Excitation = 658 nm, Emission = 675 nm)

Antibody Source

Monoclonal Mouse IgG2B Clone # 1058033
View all LILRB5/CD85c/LIR-8 Primary Antibodies »

Product Specifications

Specificity

Detects human LILRB5/CD87c/LIR-8 in direct ELISA.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2B

Applications for Human LILRB5/CD85c/LIR-8 Alexa Fluor™ Plus 647‑conjugated Antibody

Application
Recommended Usage

Immunocytochemistry

Optimal dilution of this antibody should be experimentally determined.

Background: LILRB5/CD85c/LIR-8

LIR8, also known as CD85c and LILRB5, belongs to the Leukocyte immunoglobulin-like receptors (LILR) family of transmembrane glycoproteins involved in regulating immune responses (1,2). There are at least thirteen LILR family members and are divided into activating (LILRA) or inhibiting (LILRB) molecules (1, 2). Mature human LIR8 consists of an extracellular domain (ECD) with four Ig-like domains, a transmembrane segment, and a cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). Alternative splicing of human LIR8 generates at least 2 isoforms, one lacking the second Ig-like domain. The LILR family appears to be primate-specific receptors in terms of sequence homology. LIR8 is expressed on NK cells and in the tryptic granules of mast cells and negatively regulates immune cell activation (3, 4) It is present on the mast cell surface following cell activation and degranulation (4). Activated mast cells may also release soluble forms of LIR8 (3). LIR8 has also been shown to be expressed on T cells and induce CD8+ T cell proliferation (5). Consistent with the demonstrated binding of LILRB2 to Angiopoietin-like 2 and 5 (6), R&D Systems in-house testing indicates that LIR8 binds to Angiopoietin-like 7. Recently, a common missense variant of LIR8 was found to be associated with statin intolerance and myalgia (7).

References

  1. Brown, D. et al. (2004) Tissue antigens. 64:215.
  2. Thomas, R. et al. (2010) Clin. Rev. Allergy Immunol. 38:159.
  3. Borges, L. et al. (1997) J. Immunol. 159:5192.
  4. Tedla, N. et al. (2008) J. Leukoc. Biol. 83:334.
  5. Hogan, H. E. et al. (2016) Sci Rep. 6:21780.
  6. Zheng, J. et al. (2012) Nature 485:656.
  7. Siddigui, M. et al. (2017) Eur. Heart J. 38:3569.

Long Name

Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM And ITIM Domains), Member 5

Alternate Names

CD85c, LIR-8, LIR8

Entrez Gene IDs

10990 (Human); 102129427 (Cynomolgus Monkey)

Gene Symbol

LILRB5

UniProt

O75023

Additional LILRB5/CD85c/LIR-8 Products

Product Documents for Human LILRB5/CD85c/LIR-8 Alexa Fluor™ Plus 647‑conjugated Antibody

Certificate of Analysis

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Product Specific Notices for Human LILRB5/CD85c/LIR-8 Alexa Fluor™ Plus 647‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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