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Human LINGO-2 Antibody

Catalog #: AF3679
1 Citation Datasheet / COA / SDS

Discontinued Product

AF3679 has been discontinued.
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Citations (1)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human LINGO-2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human LINGO-2 in direct ELISAs and Western blots. In direct ELISAs, less than 5% cross-reactivity with recombinant human
LINGO‑1 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human LINGO-2
Cys28-Leu542
Accession # Q7L985
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human LINGO‑2
Immunocytochemistry
5-15 µg/mL
Immersion fixed A549 human lung carcinoma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: LINGO-2

LINGO-2, also known as Leucine-rich repeat neuronal 6C (LRRN6C), is a type I transmembrane protein in the neuronal leucine-rich repeat family. These proteins have a signal peptide, 12 extracellular leucine-rich repeats flanked by N-terminal and C-terminal cysteine-rich sequences, an immunoglobulin-like domain, a transmembrane domain and a short cytoplasmic tail. Human LINGO-2 is a 606 amino acid protein with unknown functions. It is highly conserved, sharing 99% and 98% aa sequence identity with canine and mouse LINGO-2, respectively.

Long Name
Leucine-rich Repeat And Ig Domain Containing Nogo Receptor-Interacting Protein 2
Entrez Gene IDs
158038 (Human); 242384 (Mouse); 313156 (Rat)
Alternate Names
LERN3; LERN3FLJ31810; leucine rich repeat and Ig domain containing 2; leucine-rich repeat and immunoglobulin-like domain-containing nogoreceptor-interacting protein 2; Leucine-rich repeat neuronal protein 3; Leucine-rich repeat neuronal protein 6C; LINGO2; LINGO-2; LRRN6C; LRRN6Cleucine rich repeat neuronal 6C

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Citation for Human LINGO-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths
    Authors: NM Belle, Y Ji, K Herbine, Y Wei, J Park, K Zullo, LY Hung, S Srivatsa, T Young, T Oniskey, C Pastore, W Nieves, M Somsouk, DR Herbert
    Nat Commun, 2019-09-27;10(1):4408.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P

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