Human/Mouse BACE-1 Ectodomain Alexa Fluor® 647-conjugated Antibody Summary
Accession # P56817
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
BACE-1 (beta‑site APP cleaving enzyme-1) is an aspartic protease and an integral membrane protein (1, 2). It is the major beta secretase, and together with the gamma secretase, is responsible for generating the amyloid beta peptide (A beta ) from the amyloid precursor protein (APP) (3, 4). Because A beta is a major component of amyloid plaques, BACE-1 has been implicated in the onset and/or progression of Alzheimer's disease. High levels of BACE-1 activity are sufficient to elicit neurodegeneration and neurological decline in vivo, indicating that inhibiting BACE-1 may block not only A beta -dependent but also A beta -independent pathogenic mechanisms (5). In addition to APP, BACE-1 also cleaves APP-like proteins 1 and 2, the cell adhesion protein P-selectin glycoprotein ligand-1 and beta -galactoside alpha 2,6-sialyltransferase, implying that BACE-1 may have additional functions involving the ectodomain shedding of membrane proteins (6‑8).
- Vassar, R. et al. (1999) Science 286:735.
- Yan, R. et al. (1999) Nature 402:533.
- Cai, H. et al. (2001) Nature Neurosci. 4:233.
- Roberds, S.L. et al. (2001) Human Mol. Genet. 97:1317.
- Rockenstein, E. et al. (2005) J. Biol. Chem. 280:32957.
- Li, Q and T.C. Sudhof (2004) J. Biol. Chem. 279:10542.
- Lichtenthaler, S.F. et al. (2003) J. Biol. Chem. 278:48713.
- Kitazynem, S. et al. (2005) J. Biol. Chem. 280:8589.
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