Human/Mouse HIF-1 alpha/HIF1A Antibody
Human/Mouse HIF-1 alpha/HIF1A Antibody Summary
Arg575-Asn826
Accession # Q16665.1
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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HIF-1 alpha/HIF1A in Human Kidney Cancer Tissue. HIF-1 alpha/HIF1A was detected in immersion fixed paraffin-embedded sections of human kidney cancer tissue using Mouse Anti-Human/Mouse HIF-1 alpha/HIF1A Monoclonal Antibody (Catalog # MAB1935) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: HIF-1 alpha/HIF1A
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha ) is the regulated member of the transcription factor heterodimer HIF-1. HIF-1 binds to hypoxia-response elements (HREs) in the promoters of many genes involved in adapting to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF-1 alpha.
Product Datasheets
Citations for Human/Mouse HIF-1 alpha/HIF1A Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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microRNA-142 guards against autoimmunity by�controlling�Treg�cell homeostasis and function
Authors: WL Wang, C Ouyang, NM Graham, Y Zhang, K Cassady, EY Reyes, M Xiong, AM Davis, K Tang, D Zeng, MP Boldin
PloS Biology, 2022;20(2):e3001552.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Tumor hypoxia represses &gamma&delta T cell-mediated antitumor immunity against brain tumors
Authors: JH Park, HJ Kim, CW Kim, HC Kim, Y Jung, HS Lee, Y Lee, YS Ju, JE Oh, SH Park, JH Lee, SK Lee, HK Lee
Nature Immunology, 2021;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells
Authors: Y Sun, X Lin, B Liu, Y Zhang, W Li, S Zhang, F He, H Tian, X Zhu, X Liu, J Wu, J Cai, M Li
Science Advances, 2021;7(52):eabj6877.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Celastrol mediates Th17 and Treg cell generation via metabolic signaling
Authors: J Zhang, J Shan, X Chen, S Li, D Long, Y Li
Biochem. Biophys. Res. Commun., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Dendritic cell SIRT1-HIF1alpha axis programs the differentiation of CD4+ T cells through IL-12 and TGF-beta1.
Authors: Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
Proc Natl Acad Sci U S A, 2015;112(9):E957-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development.
Authors: Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson T, Rankin E, Giaccia A, Schipani E
Dev Biol, 2014;393(1):124-36.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Effects of sustained antiangiogenic therapy in multistage prostate cancer in TRAMP model.
Authors: Isayeva T, Chanda D, Kallman L, Eltoum IE, Ponnazhagan S
Cancer Res., 2007;67(12):5789-97.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8.
Authors: Liu L, Xie F, Chang K, Li M, Meng Y, Wang X, Li H, Li D, Yu J
Int J Clin Exp Pathol, 0;7(2):575-83.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P
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