Human/Mouse PGPEP-1 Alexa Fluor® 405-conjugated Antibody

Catalog #: AF6278V Datasheet / COA / SDS

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AF6278V-100UG

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All PGPEP-1 Antibodies

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Human/Mouse PGPEP-1 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human PGPEP-1 in direct ELISAs and, human and mouse PGPEP-1 in Western blots.

Source

Polyclonal Sheep IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human PGPEP-1
Met1-His209
Accession # Q9NXJ5

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PGPEP-1

Pyroglutamyl peptidase-1 (PGPEP-1) is an omega peptidase which removes pyroglutamyl residues from the amino termini of peptides and proteins (1). It is a cytosolic cysteine peptidase that is expressed in most cell types (2). The enzyme requires a thiol‑reducing agent for activity (3). PGPEP-1 is potentially involved in the inactivation of biologically active peptides that possess an amino terminal pyroglutamyl group (3). Examples of such peptides include neurotensin, luteinizing hormone releasing hormone, and thyrotropin-releasing hormone. Human and mouse PGPEP-1 share 95% aa sequence identity.

Long Name

Pyroglutamyl Aminopeptidase I

Entrez Gene IDs

54858 (Human)

Alternate Names

EC 3.4.19.3; PAP-I; Pcp; PGPEP1; PGPEP-1; PGPIFLJ20208; PGP-IPAP-I; PGPMGC10812; Pyroglutamyl aminopeptidase I; pyroglutamyl-peptidase 1; pyroglutamyl-peptidase I5-oxoprolyl-peptidase; Pyrrolidone-carboxylate peptidase