ARHGAP1 (also p50-RhoGAP and CDC42 GTPase-activating protein) is a 50 kDa member of the ARHGAP family of proteins. It is preferentially expressed in epithelium, and serves as a cytoplasmic protein that deactivates Rho-family GTPases. It does so by contributing an Arg residue (Arg282) to Cdc42 and RhoA, which activates their intrinsic GTPase activity and converts GTP-associated molecules into inactivating GDP molecules. Human ARHGAP1 is 439 amino acids (aa) in length and contains one CRAL-TRIO domain that binds small lipophilic molecules (aa 53‑218), an SH3 binding site (aa 228‑238) and one C‑terminal RhoGAP domain (aa 244‑431). There are phosphorylation sites at Ser51 and Tyr65. There is one potential splice form with a 24 aa substitution for aa 1‑150 coupled to a 26 aa substitution for aa 300‑439. Over aa 1‑62, human ARHGAP1 shares 96% aa identity with mouse ARHGAP1.
Human/Mouse/Rat ARHGAP1 Alexa Fluor™ Plus 594‑conjugated Antibody
R&D Systems | Catalog # AF6407AFP594
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Applications for Human/Mouse/Rat ARHGAP1 Alexa Fluor™ Plus 594‑conjugated Antibody
Western Blot
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Background: ARHGAP1
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Product Documents for Human/Mouse/Rat ARHGAP1 Alexa Fluor™ Plus 594‑conjugated Antibody
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Product Specific Notices for Human/Mouse/Rat ARHGAP1 Alexa Fluor™ Plus 594‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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