Human/Mouse/Rat ARHGAP1 Antibody

ARHGAP1 (also p50-RhoGAP and CDC42 GTPase-activating protein) is a 50 kDa member of the ARHGAP family of proteins. It is preferentially expressed in epithelium, and serves as a cytoplasmic protein that deactivates Rho-family GTPases. It does so by contributing an Arg residue (Arg282) to Cdc42 and RhoA, which activates their intrinsic GTPase activity and converts GTP-associated molecules into inactivating GDP molecules. Human ARHGAP1 is 439 amino acids (aa) in length and contains one CRAL-TRIO domain that binds small lipophilic molecules (aa 53‑218), an SH3 binding site (aa 228‑238) and one C‑terminal RhoGAP domain (aa 244‑431). There are phosphorylation sites at Ser51 and Tyr65. There is one potential splice form with a 24 aa substitution for aa 1‑150 coupled to a 26 aa substitution for aa 300‑439. Over aa 1‑62, human ARHGAP1 shares 96% aa identity with mouse ARHGAP1.