Human/Mouse/Rat DRAK2 Alexa Fluor® 405-conjugated Antibody

Catalog #: FAB6640V Datasheet / COA / SDS

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FAB6640V-100UG

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Human/Mouse/Rat DRAK2 Alexa Fluor® 405-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat DRAK2 in Western blots. In Western blots, less than 10% cross-reactivity with recombinant human (rh) DRAK1, rhDAPK1, rhDAPK2, or rhDAPK3 is observed.

Source

Monoclonal Mouse IgG2b Clone # 685228

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human DRAK2
Ala87-Glu285 (predicted)
Accession # O94768

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 405 (Excitation= 405 nm, Emission= 421 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: DRAK2

DRAK2 (death-associated protein related kinase-2), also called STK17B (Ser/Thr kinase 17B) is a 45 kDa member of the DAPK (death-associated protein kinase) family. It is expressed mainly in lymphoid organs by mature T cells and B cells. It is autophosphorylated on Ser12 after TCR stimulation and negatively regulates TCR signaling. Ultraviolet light causes phosphorylation on Ser350 and translocation to the nucleus to stimulate apoptosis. Within the region used as an immunogen, human DRAK2 shares 95% amino acid (aa) identity with mouse and rat DRAK2 while mouse and rat DRAK2 share 99.5% aa identity.

Long Name

DAP Kinase-related Apoptosis-inducing Protein Kinase 2

Entrez Gene IDs

9262 (Human)

Alternate Names

DAP kinase-related apoptosis-inducing protein kinase 2; DRAK2; DRAK2death-associated protein kinase-related 2; EC 2.7.11; EC 2.7.11.1; serine/threonine kinase 17b (apoptosis-inducing); serine/threonine kinase 17b; serine/threonine-protein kinase 17B; STK17B