Human/Mouse/Rat IMP2 Alexa Fluor™ Plus 405‑conjugated Antibody

R&D Systems | Catalog # AF5305AFP405

R&D Systems

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Alexa Fluor Plus 405 (Excitation = 404 nm, Emission = 455 nm)

Antibody Source

Polyclonal Goat IgG
View all IMP2 Primary Antibodies »

Product Specifications

Specificity

Detects endogenous human, mouse and rat IMP2 isoforms in Western blots. Reactivity with other IMP family members is unknown.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for Human/Mouse/Rat IMP2 Alexa Fluor™ Plus 405‑conjugated Antibody

Application
Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: IMP2

IMP2 (IGF-II mRNA-binding protein 2; also VICKZ family member 2) is a 62 kDa member of the RRM IMP/VICKZ family of proteins. It is expressed in oocytes, spermatogonia, Leydig cells and follicular granulosa cells. IMP2 binds to AUF1, a binding protein for the AU-rich motifs of mRNA, and facilitates the degradation of cytokine and protooncogene mRNAs. Human IMP2 is 556 amino acids (aa) in length. It contains two RNA recognition regions (aa 3‑76 and 82‑157), and four KH domains (aa 193‑532) that mediate RNA binding. There are multiple splice variants. One shows an insertion of 43 aa after Asn357, a second shows a 17 aa substitution for the N-terminal 80 aa, a third shows a combination of the prior two, and a fourth shows a 15 aa substitution for aa 414‑556. Over aa 1‑220, human IMP2 is 89% aa identical to mouse IMP2.

Long Name

Insulin-like Growth Factor 2 mRNA Binding Protein 2

Alternate Names

IF2B2, IGF2BP2, VICKZ2

Entrez Gene IDs

10644 (Human); 319765 (Mouse); 303824 (Rat)

Gene Symbol

IGF2BP2

UniProt

Q9Y6M1

Additional IMP2 Products

Product Documents for Human/Mouse/Rat IMP2 Alexa Fluor™ Plus 405‑conjugated Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Product Specific Notices for Human/Mouse/Rat IMP2 Alexa Fluor™ Plus 405‑conjugated Antibody


This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only

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