Human/Mouse/Rat IMP2 Antibody

IMP2 (IGF-II mRNA-binding protein 2; also VICKZ family member 2) is a 62 kDa member of the RRM IMP/VICKZ family of proteins. It is expressed in oocytes, spermatogonia, Leydig cells and follicular granulosa cells. IMP2 binds to AUF1, a binding protein for the AU-rich motifs of mRNA, and facilitates the degradation of cytokine and protooncogene mRNAs. Human IMP2 is 556 amino acids (aa) in length. It contains two RNA recognition regions (aa 3‑76 and 82‑157), and four KH domains (aa 193‑532) that mediate RNA binding. There are multiple splice variants. One shows an insertion of 43 aa after Asn357, a second shows a 17 aa substitution for the N-terminal 80 aa, a third shows a combination of the prior two, and a fourth shows a 15 aa substitution for aa 414‑556. Over aa 1‑220, human IMP2 is 89% aa identical to mouse IMP2.