Home / MIOS / Human/Mouse/Rat MIOS Alexa Fluor® 594-conjugated Antibody

Human/Mouse/Rat MIOS Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB9289T Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB9289T-100UG

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Human/Mouse/Rat MIOS Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human MIOS in direct ELISAs and Western blots.
Source
Monoclonal Mouse IgG1 Clone # 955413
Purification
Protein A or G purified
Immunogen
Human MIOS synthetic peptide
Accession # Q9NXC5
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Label
Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration
Sample
Western Blot
Optimal dilution of this antibody should be experimentally determined.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: MIOS

MIOS is a member of the octameric GATOR (GTPase-activating protein (GAP) activity toward RAGs) complex.  MIOS and fellow GATOR2 subcomplex members WDR24, WDR59, SEH1L and SEC13 inhibit GATOR1 subcomplex members DEPDC5, NPRL2 and NPRL3.  This inhibition by GATOR2 positively regulates mTORC1 signaling, an activity modulated by energy levels, growth factors, and amino acids.  Human MIOS is 875 amino acids (aa) in length, and contains six N-terminal WD40 repeats and a C-terminal zinc finger-like domain.  Over aa 620-875, human MIOS shares 98% identity with mouse and rat MIOS.

Long Name
Missing Oocyte, Meiosis Regulator
Entrez Gene IDs
54468 (Human); 252875 (Mouse); 362324 (Rat)
Alternate Names
FLJ20323; MIO; MIOS; missing oocyte, meiosis regulator, homolog (Drosophila); WD repeat-containing protein mio

Product Datasheets

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