Human/Mouse/Rat Protocadherin-17 Alexa Fluor® 594-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Protocadherin-17

Protocadherin 17 (PCDH-17) is a 120-150 kDa glycoprotein, δ2-group member of the of the protocadherin subfamily, cadherin family of molecules. It is expressed on endothelium and epithelium such as stratified squamous epithelium and (likely) gastric columnar epithelium. PCDH17 is posited to act as an adhesion molecule, and appears to play a role in promoting cell cycle arrest and inhibiting migration. Mature human PCDH-17 is a type I transmembrane protein that is 1142 amino acids (aa) in length. It contains a 690 aa extracellular domain (ECD) (aa 18-707) plus a 431 aa cytoplasmic region. There are 6 cadherin domains in the ECD (aa 18-695). Two splice forms are reported that involve substitutions in the cytoplasmic region. The first possesses a 14 aa substitution, while the second shows a 25 aa substitution, both for aa 876-1159. Over aa 18-705, human PCDH-17 shares 98% aa identity with mouse PCDH-17.

Product Datasheets

Related Research Areas

• Cadherin Superfamily