Human/Mouse/Rat Rap2A/B Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB4698S Datasheet / COA / SDS

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FAB4698S-100UG

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All Rap2A/B Antibodies

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Human/Mouse/Rat Rap2A/B Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human, Mouse, Rat

Specificity

Detects human, mouse, and rat Rap2A/B in Western blots.

Source

Monoclonal Mouse IgG2b Clone # 455410

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human Rap2A/B
Met1-Gln183
Accession # P10114

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Rap2A/B

Rap2A and Rap2B are members of the small GTPase superfamily and ras family of proteins. Both proteins are 183 amino acids (aa) in length (SwissProt P10114 and P61225), and they are 90% identical at the amino acid level, with the most variability at the carboxyl terminus of the protein. Unlike normal Ras proteins that have a nontransforming glutamine at aa 61, these two oncogenic proteins have a threonine in that position. This change makes the intrinsic GTPase activity for these proteins lower, thereby allowing them to exist in the activated state for a longer period of time than normal Ras proteins.

Long Name

Ras-related Protein 2A/B

Alternate Names

KREV;K-REV;RAP2;Ras-related protein Rap-2a;RbBP-30; Rap2A/B