Human/Mouse Serpin I1 Alexa Fluor® 350-conjugated Antibody

Catalog #: FAB3124U Datasheet / COA / SDS

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FAB3124U-100UG

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Human/Mouse Serpin I1 Alexa Fluor® 350-conjugated Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse SerpinI1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross reactivity with recombinant mouse Serpin I1 is observed and no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A12

Source

Monoclonal Rat IgG2a Clone # 437016

Purification

Protein A or G purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Serpin I1
Ala19-Leu410
Accession # AAH18043

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 350 (Excitation= 346 nm, Emission= 442 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Serpin I1

Serpin I1, also known as neuroserpin, is a secreted serine protease inhibitor predominantly expressed in the brain. Serpin I1 defects cause familial encephalopathy with neuroserpin inclusion bodies (FEN1B), an autosomal dominant dementia. The amino acid sequence of human Serpin I1 is 99%, 93%, 88%, 86% and 80% identical to that of chimpanzee, dog, rat, mouse and chicken.

Entrez Gene IDs

5274 (Human); 20713 (Mouse); 116459 (Rat)

Alternate Names

DKFZp781N13156; Neuroserpin; Peptidase inhibitor 12; PI12; PI-12; PI12Serpin I1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; Serpin I1; serpin peptidase inhibitor, clade I (neuroserpin), member 1