Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # 437016
View all Serpin I1 Primary Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Serpin I1
Ala19-Leu410
Accession # AAH18043

Specificity

Detects human and mouse SerpinI1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross reactivity with recombinant mouse Serpin I1 is observed and no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A12, B6, B8, B9, C1, D1, F2, G1, or I2 is observed.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for Human/Mouse Serpin I1 Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human and Mouse Serpin I1

Formulation, Preparation, and Storage

Purification

Protein A or G purified from hybridoma culture supernatant

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Calculators

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Serpin I1

Serpin I1, also known as neuroserpin, is a secreted serine protease inhibitor predominantly expressed in the brain. Serpin I1 defects cause familial encephalopathy with neuroserpin inclusion bodies (FEN1B), an autosomal dominant dementia. The amino acid sequence of human Serpin I1 is 99%, 93%, 88%, 86% and 80% identical to that of chimpanzee, dog, rat, mouse and chicken.

Alternate Names

Neuroserpin, PI12

Entrez Gene IDs

5274 (Human); 20713 (Mouse); 116459 (Rat)

Gene Symbol

SERPINI1

UniProt

AAH18043

Additional Serpin I1 Products

Product Documents for Human/Mouse Serpin I1 Antibody

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

Download SDS

Product Specific Notices for Human/Mouse Serpin I1 Antibody

For research use only

Related Research Areas

Serine Proteases and Regulators

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