|Flow Cytometry HEK293 human embryonic kidney cell line transfected with human MS4A4A and eGFP was stained with either (A) Mouse Anti-Human MS4A4A PE‑conjugated Monoclonal Antibody (Catalog # FAB7797P) or (B) Mouse IgG2B Phycoerythrin Isotype Control (Catalog # IC0041P). View our protocol for Staining Membrane-associated Proteins.|
MS4A4A, also called CD20-like 1, is a 23 kDa (predicted) member of the MS4A family of four-transmembrane proteins that includes CD20 (MS4A1) and Fce RIb (MS4A2). MS4A4 cDNA is detected in hematopoietic cell lines, with highest expression in myeloid and B cell lines. Expressed sequence tags are detected in multiple organs and tissues. Human MS4A4A shares ~60% amino acid sequence identity with mouse and rat MS4A4A, if sequence gaps at the cytoplasmic N and C termini are disregarded. One potential isoform lacks aa 130-182, which includes the 3rd transmembrane segment and the first of two extracellular regions.
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