Human NAALADase-2/NAALAD2 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB7658R Datasheet / COA / SDS

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FAB7658R-100UG

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Human NAALADase-2/NAALAD2 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human NAALADase-2/NAALAD2 in direct ELISAs. In direct ELISAs, approximately 50% cross-reactivity with recombinant mouse NAALADase-2 is observed and no cross-reactivity with recombinant human (rh) PSMA/FOLH1/NAALADase-1, rhNAALADase-like 2, or rh

Source

Monoclonal Mouse IgG2b Clone # 756030

Purification

Protein A or G purified

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human NAALADase-2/NAALAD2
Lys32-Leu740
Accession # Q9Y3Q0

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NAALADase-2/NAALAD2

N-acetylated-alpha-linked acidic dipeptidase 2 (NAALADase-2), also known as glutamate carboxypeptidase 3 (GCP3), is a 90-100 kDa type 2 transmembrane protein in the M28 peptidase family. It hydrolyzes beta-citrylglutamate (BCG) and N-acetyl-aspartylglutamate (NAAG) which are abundant dipeptides found in brain and testis. Mature human NAALADase-2 consists of a 7 amino acid (aa) cytoplasmic domain, a 24 aa transmembrane segment, and a 709 aa extracellular region (aa 32-740) that contains the peptidase domain. Over aa 32-740, human NAALADase-2 shares 89% aa sequence identity with mouse NAALADase-2.

Long Name

N-Acetylated Alpha-Linked Acidic Dipeptidase 2

Entrez Gene IDs

10003 (Human); 72560 (Mouse); 300384 (Rat)

Alternate Names

GCPIII; Glutamate Carboxypeptidase III; GPCIII; MGC116996; MGC26353; NAADALASE2; NAALAD2; NAALADase II; NAALADase2; NAALADase-2; N-acetylated alpha-linked acidic dipeptidase 2; N-acetylated alpha-linked acidic dipeptidase II; N-acetylated-alpha-linked acidic dipeptidase 2; N-acetylated-alpha-linked acidic dipeptidase II