Human NGL-3/LRRC4B (NP_001073926) VersaClone cDNA

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R&D Systems VersaClone cDNA Plasmids
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Product Details

Human NGL-3/LRRC4B (NP_001073926) VersaClone cDNA Summary


Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: NGL-3/LRRC4B

Netrins have been identified as midline-derived chemoattractants that guide axons to the midline during development. Netrins are antagonized by Slit and Robo proteins which compete for DCC (deleted in colorectal cancer) receptor binding. Netrins also have axon repulsion effects when interacting with the UNC5 (uncoordinated-5) receptor family, either alone or with DCC receptors. Netrins are a laminin-related family of matrix-binding secreted proteins containing an N-terminal laminin gamma-chain-related globular domain (domain VI), three laminin EGF-like repeats, and a C-terminal heparin-binding domain.

Netrin-G1a and Netrin-G2a are members of the GPI-linked Netrin subfamily distantly related to classic Netrins. Membrane-bound G-type Netrins are suggested to promote neurite outgrowth and perhaps impact neuronal plasticity. G-type Netrins are found only in vertebrates. Netrin-G1a and Netrin-G2a contain an N-terminal laminin globular domain (domain VI) followed by 3 laminin EGF-like repeats, and a C-domain with a hydrophobic signal for glycosylphosphatidylinositol (GPI) lipid linkage. The Netrin-G2a molecule also contains a C-terminal heparin binding site.

Long Name
Netrin-G3 Ligand/Leucine-rich Repeat Containing 4B
Entrez Gene IDs
94030 (Human); 272381 (Mouse); 308571 (Rat)
Alternate Names
DKFZp761A179; HSM; Leucine Rich Repeat Containing 4B; Leucine-Rich Repeat-Containing Protein 4B; Leucine-Rich Repeats And Immunoglobulin-Like Domains 4; LRIG4; LRRC4B; Netrin-G3 Ligand; NGL3; NGL-3


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