NKG2A and NKG2C are type II transmembrane proteins with extracellular C-type lectin domains. These proteins heterodimerize with CD94 to form complexes that recognize HLA-E as ligand. The NKG2A/CD94 complex delivers an inhibitory signal resulting from ITIMs within the NKG2A cytoplasmic domain. NKG2C/CD94 provides an activating signal due to association with the ITAM-containing DAP12 adapter protein. These complexes are expressed on NK and T cell subsets.
Human NKG2A/CD159a (NP_002250) VersaClone cDNA
R&D Systems | Catalog # RDC2583
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Background: NKG2A/CD159a
Long Name
Natural Killer G2A
Alternate Names
CD159a, Klrc1, NKG2
Gene Symbol
KLRC1
UniProt
Additional NKG2A/CD159a Products
Product Documents for Human NKG2A/CD159a (NP_002250) VersaClone cDNA
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Product Specific Notices for Human NKG2A/CD159a (NP_002250) VersaClone cDNA
For research use only
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Associated Pathways
