Human NT-4 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB268R Datasheet / COA / SDS

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FAB268R-100UG

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Human NT-4 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human NT-4 in direct ELISAs and Western blots. In Western blots, this antibody shows less than 1% cross‑reactivity with recombinant human (rh) NT-3 and rhBDNF.

Source

Monoclonal Mouse IgG1 Clone # 36526

Purification

Protein A or G purified

Immunogen

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human NT-4

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: NT-4

NT-4 was originally identified as a mammalian homolog of the Xenopus neurotrophin, NT-4. Along with NGF, BDNF, and NT-3, it is a member of the NGF family of neurotrophic factors that are required for the differentiation and survival of specific neuronal subpopulations in both the central and the peripheral nervous systems. NT-4 functions through interactions with the TrkB receptor tyrosine kinase. Because mammalian NT-4 is much more divergent from its amphibian functional counterpart (Xenopus NT-4) than other family members, it is sometimes designated NT-5 or NT-4/5.

Long Name

Neurotrophin 4

Entrez Gene IDs

4909 (Human)

Alternate Names

GLC10; GLC1O; neurotrophic factor 4; neurotrophic factor 5; neurotrophin 4; neurotrophin 5 (neurotrophin 4/5); neurotrophin-4; neurotrophin-5; Neutrophic factor 4; NT4; NT-4; NT-4/5; NT-5; NTF4; NTF5; NTF5NT5