Human Phospho-PYK2/FAK2 (Y402) Alexa Fluor® 594-conjugated Antibody

Catalog #: FAB6210T Datasheet / COA / SDS

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FAB6210T-100UG

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Human Phospho-PYK2/FAK2 (Y402) Alexa Fluor® 594-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human PYK2/FAK2 when phosphorylated at Y402.

Source

Monoclonal Mouse IgG1 Clone # 592918

Purification

Protein A or G purified

Immunogen

Phosphopeptide containing the human PYK2/FAK2 Y402 site
Accession # Q14289

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 594 (Excitation= 590 nm, Emission= 617 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: PYK2/FAK2

PYK2 (Proline-rich kinase 2; also Ptk2b, Fak2, RAFTK and CAK beta ) is a 112‑116 kDa member of the Fak subfamily, tyrosine protein kinase family. It is expressed in multiple cell types, including endothelial cells, vascular smooth muscle cells, megakaryocytes and neurons. PYK2 is activated by elevated intracellular Ca⁺⁺ and is associated with MAPK pathway activation. Human PYK2 is 1009 amino acids (aa) in length. PYK2 phosphorylation at Tyr402 is associated with enzymatic activation, intercellular localization, cell growth, cell motility, and regulating molecular associations. Over aa 390‑410, human PYK2 is 100% aa identical to mouse PYK2.

Long Name

Proline-rich Tyrosine Kinase 2

Entrez Gene IDs

2185 (Human); 19229 (Mouse); 50646 (Rat)

Alternate Names

CADTK; CADTKCAK-beta; CAK beta; CAKB; Calcium-dependent tyrosine kinase; Cell adhesion kinase beta; EC 2.7.10; FADK2; FAK2; FAK2EC 2.7.10.2; Focal adhesion kinase 2; FRNK; PKB; ppyk2; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2B protein tyrosine kinase 2 beta; PTK2B; PYK2; PYK2Related adhesion focal tyrosine kinase; RAFTK; RAFTKFADK 2