Human PIWIL1/HIWI (NP_004755) VersaClone cDNA

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Human PIWIL1/HIWI (NP_004755) VersaClone cDNA
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Human PIWIL1/HIWI (NP_004755) VersaClone cDNA Summary


Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

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Background: PIWIL1/HIWI

PIWIL1 (piwi-like 1), also called HIWI (human homolog of drosophila piwi), is a cytoplasmic protein of the PIWI subgroup of the Argonaute family. PIWI domains bind a class of ~29-30 nucleotide RNAs termed piRNAs (piwi domain-binding RNAs). PIWIL1 orthologs are expressed with piRNAs in germ cells and are essential for spermatogenesis in mice. CD34+ hematopoietic progenitor cell PIWIL1 is downregulated upon differentiation. When overexpressed in leukemic cell lines, PIWIL1 inhibits growth and induces apoptosis.

Long Name
Piwi-like Protein 1
Entrez Gene IDs
9271 (Human)
Alternate Names
HIWI; HIWIpiwi homolog; MIWI; piwi (Drosophila)-like 1; PIWI; PIWIL1; piwi-like 1 (Drosophila); piwi-like protein 1


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