Human Podocalyxin NL557 MAb (Clone 222328)

R&D Systems | Catalog # NL1658R

R&D Systems
Discontinued Product
NL1658R has been discontinued. View all Podocalyxin products.

Key Product Details

Species Reactivity

Human

Applications

Immunocytochemistry

Label

NL557 (Excitation = 557 nm, Emission = 574 nm)

Antibody Source

Monoclonal Mouse IgG2A Clone # 222328
View all Podocalyxin Primary Antibodies »

Product Specifications

Specificity

Detects human Podocalyxin in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant mouse Podocalyxin or recombinant human Endoglycan is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Human Podocalyxin NL557 MAb (Clone 222328)

Application
Recommended Usage

Immunocytochemistry

Optimal dilutions of this antibody should be experimentally determined.

Background: Podocalyxin

Podocalyxin, also known as Podocalyxin-like protein-1 (PCLP1 or PODXL), is a type I transmembrane glycoprotein. It belongs to the CD34/Podocalyxin family of sialomucins that share structural similarity and sequence homology (1). Podocalyxin is a major sialoprotein in the podocytes of the kidney glomerulus and is also expressed by both endothelium and multipotent hematopoietic progenitors (2). It has been identified as a novel cell surface marker for hemangioblasts, the common precursors of hematopoietic and endothelial cells.

References

  1. Li, J. et al. (2001) DNA Seq. 12:407.
  2. Hara, T. et al. (1999) Immunity 11:567.

Alternate Names

GCTM, PCLP, POD XL, PODXL

Entrez Gene IDs

5420 (Human); 27205 (Mouse)

Gene Symbol

PODXL

UniProt

AAB61574

Additional Podocalyxin Products

Product Documents for Human Podocalyxin NL557 MAb (Clone 222328)

Certificate of Analysis

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Product Specific Notices for Human Podocalyxin NL557 MAb (Clone 222328)

For research use only

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