Human Presenilin-2 C-Terminal Fragment Alexa Fluor® 488-conjugated Antibody

Catalog #: AF197G Datasheet / COA / SDS

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AF197G-100UG

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Human Presenilin-2 C-Terminal Fragment Alexa Fluor® 488-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Presenilin‑2 C-Terminal Fragment in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross‑reactivity with recombinant human (rh) Presenilin‑1 N‑Terminal Fragment (aa 1‑80), rhPr

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Presenilinâ€‘2 C-Terminal Fragment
Glu322-Thr388
Accession # P49810

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 488 (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: Presenilin-2

Presenilin-1 (PS-1) and Presenilin-2 (PS-2) are integral membrane proteins that contain multiple transmembrane domains. Both are predominantly located within the endoplasmic reticulum (ER) and early Golgi apparatus. They are primarily expressed in neurons and are ubiquitously expressed in the brain. PS-1 and PS-2 are proteolytically cleaved to generate an N-terminal fragment (NTF) and a C-terminal fragment (CTF). Mutations in the gene for Presenilin may play an important role in the pathology of Alzheimer's disease.

Entrez Gene IDs

5664 (Human)

Alternate Names

AD3LP; AD4AD3L; AD5; E5-1; EC 3.4.23; EC 3.4.23.-; presenilin 2 (Alzheimer disease 4); Presenilin2; Presenilin-2; PS-2; PS2CMD1V; PSEN2; PSNL2; STM2STM-2