Human RARRES1 Antibody

Catalog # Availability Size / Price Qty
AF4255
AF4255-SP

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Detection of Human RARRES1 by Western Blot.
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Product Details
Citations (3)
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Human RARRES1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human RARRES1 in direct ELISAs and Western blots.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human RARRES1
Pro43-Phe294
Accession # P49788
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human RARRES1 antibody by Western Blot. View Larger

Detection of Human RARRES1 by Western Blot. Western blot shows lysates of human heart tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human RARRES1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4255) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF019). A specific band was detected for RARRES1 at approximately 40 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 8.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: RARRES1

RARRES1 (retinoic acid receptor responder 1; also Tig1) is a member of the protease inhibitor I47 family of proteins. It is expressed in epithelium, including keratinocytes, plus prostate and breast epithelium. It is considered to be a tumor-suppressor molecule, presumably acting as an inhibitor of carboxypeptidase A. Human RARRES1 is 294 amino acids (aa) in length. It is a type II transmembrane (TM) protein with a TM segment between aa 21-42. Three potential splice variants exist. There is a 46 aa N terminal extension, a four aa substitution for aa 225-294 and a combination of these two variants. Over aa 43-294, human RARRES1 shares 75% aa identity with mouse RARRES1.

Long Name
Retinoic Acid Receptor Responder [Tazarotene-induced] 1
Entrez Gene IDs
5918 (Human); 109222 (Mouse); 310486 (Rat)
Alternate Names
RARRES1; RAR-responsive protein TIG1; retinoic acid receptor responder (tazarotene induced) 1; retinoic acid receptor responder protein 1; TIG1; TIG1Tazarotene-induced gene 1 protein

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Citations for Human RARRES1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Hypermethylation and loss of retinoic acid receptor responder 1 expression in human choriocarcinoma
    Authors: H Huebner, R Strick, DL Wachter, S Kehl, PL Strissel, R Schneider-, A Hartner, W Rascher, LC Horn, MW Beckmann, M Ruebner, FB Fahlbusch
    J. Exp. Clin. Cancer Res., 2017-11-23;36(1):165.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Epigenetic repression of RARRES1 is mediated by methylation of a proximal promoter and a loss of CTCF binding.
    Authors: Peng Z, Shen R, Li YW
    PLoS ONE, 2012-05-17;7(5):e36891.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Tumor Suppressor RARRES1 Interacts with Cytoplasmic Carboxypeptidase AGBL2 to Regulate the alpha-Tubulin Tyrosination Cycle.
    Authors: Sahab ZJ, Hall MD, Me Sung Y, Dakshanamurthy S, Ji Y, Kumar D, Byers SW
    Cancer Res., 2011-02-08;71(4):1219-28.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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