Renalase is a novel, 35‑37 kDa FAD-dependent amine oxidase that is secreted primarily by glomerular and renal tubule epithelium. It presumably degrades catecholamines and lowers blood pressure by decreasing heart rate and cardiac contractility. In addition to renal cells, Renalase is produced by skeletal and cardiac muscle fibers. The human Renalase precursor is 342 amino acids (aa) in length. It contains an FAD binding domain (aa 4‑35) that overlaps a signal sequence (aa 1‑17), followed by an amine oxidase segment (aa 75‑339). Renalase circulates as both a monomer (from kidney) and homodimer (from heart). There is one potential splice variant that shows a 22 aa substitution for aa 294‑342. Over aa 2‑342, human Renalase shows 72% aa identity to mouse Renalase.
Human Renalase Alexa Fluor™ Plus 488‑conjugated Antibody
R&D Systems | Catalog # AF5350AFP488
Key Product Details
Species Reactivity
Applications
Label
Antibody Source
Product Specifications
Specificity
Clonality
Host
Isotype
Applications for Human Renalase Alexa Fluor™ Plus 488‑conjugated Antibody
Western Blot
Formulation, Preparation, and Storage
Formulation
Shipping
Stability & Storage
Background: Renalase
Alternate Names
Gene Symbol
UniProt
Additional Renalase Products
Product Documents for Human Renalase Alexa Fluor™ Plus 488‑conjugated Antibody
Certificate of Analysis
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Product Specific Notices for Human Renalase Alexa Fluor™ Plus 488‑conjugated Antibody
This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.
For research use only
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Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
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- R&D Systems Quality Control Western Blot Protocol
- Troubleshooting Guide: Western Blot Figures
- Western Blot Conditions
- Western Blot Protocol
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- Western Blot Troubleshooting
- Western Blot Troubleshooting Guide
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