RIPK3 (), also known as RIP3, is a 518 amino acid (aa), 60 kDa phosphoprotein that contains an N-terminal protein kinase domain and a C-terminal interaction motif with which it binds RIPK1. It converts cell response to TNF-alpha from apoptosis (RIPK1 via Fas) to programmed necrosis (RIPK1/RIPK3) by inducing reactive oxygen species production. Alternately spliced human beta (252 aa) and gamma (231 aa) isoforms diverge after aa 219 and 221, respectively, and are found to antagonize RIP3.
Human RIPK3/RIP3 (NP_006862) VersaClone cDNA
R&D Systems | Catalog # RDC2118
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Formulation, Preparation, and Storage
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: RIPK3/RIP3
Long Name
Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 3
Alternate Names
RIP3
Gene Symbol
RIPK3
UniProt
Additional RIPK3/RIP3 Products
Product Documents for Human RIPK3/RIP3 (NP_006862) VersaClone cDNA
Certificate of Analysis
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Product Specific Notices for Human RIPK3/RIP3 (NP_006862) VersaClone cDNA
For research use only
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