Human RLK/TXK Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB6520S Datasheet / COA / SDS

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FAB6520S-100UG

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All RLK/TXK Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human RLK/TXK Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human RLK/TXK in direct ELISAs and Western blots.

Source

Monoclonal Mouse IgG2b Clone # 674801

Purification

Protein A or G purified

Immunogen

E.coli-derived recombinant human RLK/TXK
Trp150-Val246
Accession # P42681

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: RLK/TXK

RLK (resting lymphocyte kinase), also called TXK (T cell-expressed kinase) or PTK4, is a protein tyrosine kinase of the TEK family. It is expressed in T cells and some myeloid cells, especially in Th1 cells in inflammatory diseases such as rheumatoid arthritis and Behcet’s disease. Upon TCR stimulation, it translocates to the nucleus and induces IFN-gamma production. An alternate start site creates a resident nuclear 55 kDa form in addition to the larger (~58 kDa) form that is cytoplasmic or targeted to the plasma membrane via palmitoylation of a cysteine string motif. The region used as an immunogen is common to both forms and shares 79% and 81% amino acid identity with mouse and rat RLK, respectively.

Long Name

Resting Lymphocyte Kinase

Entrez Gene IDs

7294 (Human)

Alternate Names

BTKL; BTKLEC 2.7.10.2; EC 2.7.10; MGC22473; Protein-tyrosine kinase 4; PSCTK5; PTK4 protein tyrosine kinase 4; PTK4; RLK; TKL; TXK tyrosine kinase; TXK; tyrosine kinase; tyrosine-protein kinase TXK