Human ROR gamma /RORC/NR1F3 Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB11629R Datasheet / COA / SDS

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FAB11629R-100UG

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Human ROR gamma /RORC/NR1F3 Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects recombinant human ROR gamma T, RORA and RORB proteins in Direct ELISA.

Source

Monoclonal Mouse IgG2b Clone # 1090902

Purification

Protein A or G purified

Immunogen

E. coli-derived recombinant human RORgT
Met1-Ala100
Accession # P51449

Formulation

Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Label

Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration

Sample

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: ROR gamma/RORC/NR1F3

ROR gamma (Nuclear receptor ROR-gamma), also called RORC and NR1F3, is a member of the NR1 nuclear hormone receptor family. ROR gamma is a DNA binding transcription factor. ROR gamma is 518 amino acids (aa) in length. Deletion in mice implicates ROR gamma as being essential for lymphoid organogenesis and controlling apoptosis during thymopoiesis. Two splice forms differing in the first 24 aa have been found for this gene; isoform 2 deletes aa 1‑21 resulting in an alteration of aa 22‑24. Over aa 1‑121 human ROR gamma shares 97% identity with mouse ROR gamma.

Long Name

Retinoic Acid-Related Orphan Receptor gamma

Entrez Gene IDs

6097 (Human)

Alternate Names

MGC129539; NR1F3; Nuclear receptor ROR gamma; Nuclear receptor ROR-gamma; Nuclear receptor RZR gamma; Nuclear receptor RZR-gamma; Nuclear receptor subfamily 1 group F member 3; RAR-Related Orphan Nuclear Receptor Variant 2; RAR-related orphan receptor C; RAR-related orphan receptor gamma; retinoic acid-binding receptor gamma; retinoid-related orphan receptor gamma; Retinoid-related orphan receptor-gamma; ROR gamma; RORC; RORG; RORGMGC129539; RZRG; RZRGRZR-GAMMA; TOR