Human S100A2 Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: S100A2

S100A2 (also S100L and CaN19) is a 10 kDa member of the S100 family, EF-hand superfamily of Ca-binding proteins.  It is expressed by multiple cell types, including keratinocytes, chondrocytes, and bronchial epithelium.  S100A2 regulates both Ca and Zn (in human) within cells, and increases p53 activity.  It forms both noncovalent and covalent homodimers, and a homotetramer under certain conditions.  Human S100A2 is 98 amino acids (aa) in length.  It contains two EF-hand motifs (aa 13-48 and 51-86) plus a calcium (aa 64-75) and zinc (aa 17-22) binding site.  There is one potential alternative splice form that shows a 40 aa insertion after Gly48.  Full-length human S100A2 shares 89% and 85% aa identity with bovine and canine S100A2, respectively

Product Datasheets

Related Research Areas

• Calcium-binding Proteins and Related Molecules
• Cancer Biomarkers
• Inflammatory Mediators