Home / SF-1/NR5A1 / Human SF-1/NR5A1 MAb (Clone N1665)

Human SF-1/NR5A1 MAb (Clone N1665)

Catalog #: PP-N1665-00
2 Citations Datasheet / COA / SDS
Newer Version Available: PP-N1665-0C
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Discontinued Product

PP-N1665-00 has been discontinued and is replaced by PP-N1665-0C.

Product Details
Citations (2)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human SF-1/NR5A1 MAb (Clone N1665) Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG1 Clone # N1665
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
5-15 µg/mL
Perfusion fixed paraffin-embedded sections of rat adrenal gland
Immunoprecipitation
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: SF-1/NR5A1

Streroidogenic Factor 1 (SF-1, AD4BP, FTZ-F1; NR5A1) is considered an orphan nuclear receptor that belongs to subfamily 5. It was found to be a regulator of steroidogenic enzyme gene expression. Oxysterols are suggested as its ligands. It is expressed in all steroidogenic tissues, including the adrenal cortex, testicular Sertoli cells, and Leydig cells, ovarian theca, hypothalamus, and anterior pituitary. SF-1 plays an important role in adrenal and gonadal development, including the hypothalamic-pituitary-gonadal axis and sex determination.

Long Name
Steroidogenic Factor 1
Entrez Gene IDs
2516 (Human)
Alternate Names
AD4BP; AD4BPSTF-1; Adrenal 4-binding protein; ELP; FTZ1adrenal 4 binding protein; FTZF1; FTZF1nuclear receptor AdBP4; Fushi tarazu factor homolog 1; NR5A1; Nuclear receptor subfamily 5 group A member 1; nuclear receptor subfamily 5, group A, member 1; SF1; SF-1; SF-1POF7; SF1steroidogenic factor 1; Steroid hormone receptor Ad4BP; steroidogenic factor-1

Product Datasheets

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Citations for Human SF-1/NR5A1 MAb (Clone N1665)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Pubertal androgenization and gonadal histology in two 46,XY adolescents with NR5A1 mutations and predominantly female phenotype at birth
    Authors: M Cools, P Hoebeke, K P Wolffenbuttel, H Stoop, R Hersmus, M Barbaro et al.
    European Journal of Endocrinology
    Species: Human
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.
    Authors: Guo G, Smith A
    Development, 2010-10-01;137(19):3185-92.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot

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