Human Somatostatin R4/SSTR4 (AAA36623) VersaClone cDNA

R&D Systems | Catalog # RDC0182

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Key Product Details

Species

Human

Accession Number

AAA36623

Formulation, Preparation, and Storage

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Somatostatin R4/SSTR4

SSTR4 has been reported to be expressed in brain, gastrointestinal tract, pancreas, and prostate tissues. No ESTs have been identified. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Long Name

Somatostatin Receptor Type 4

Alternate Names

SomatostatinR4, SS4R, SSTR4

Entrez Gene IDs

6754 (Human); 20608 (Mouse); 25555 (Rat)

Gene Symbol

SSTR4

UniProt

AAA36623

Additional Somatostatin R4/SSTR4 Products

Product Documents for Human Somatostatin R4/SSTR4 (AAA36623) VersaClone cDNA

Certificate of Analysis

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Product Specific Notices for Human Somatostatin R4/SSTR4 (AAA36623) VersaClone cDNA

For research use only

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