Catalog Number: 2440
Chemical Name: 1-[3-[N-(5-Bromopyridin-2-yl)-N-(3,4-dichlorobenzyl)amino]propyl]-3-[3-(1H-imidazol-4-yl)propyl]thiourea
Biological Activity
Somatostatin sst4 receptor agonist that displays > 100-fold selectivity over sst2 receptors (Ki values are 6 and 621 nM for sst4 and sst2 receptors respectively). Potently inhibits forskolin-induced cAMP accumulation (EC50 = 26 nM).
Technical Data
  • M.Wt:
    556.35
  • Formula:
    C22H25N6Cl2SBr
  • Solubility:
    Soluble to 50 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    199522-35-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Nonpeptide somatostatin agonists with sst4 selectivity: synthesis and structure-activity relationships of thioureas.
    Liu et al.
    J.Med.Chem., 1998;41:4693
  2. 2-pyridylthioureas: novel nonpeptide somatostatin agonists with SST4 selectivity.
    Liu et al.
    Curr.Pharm.Des., 1999;5:255

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