Human STRO-1 Antibody
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Summary
Data Examples
Preparation and Storage
Reconstitution Calculator
Background
Product Datasheets
Related Research Areas
Human STRO-1 Antibody Summary
Species Reactivity
Human
Specificity
Detects human STRO-1.
Source
Monoclonal Mouse IgM Clone # STRO-1
Purification
IgM-specific Affinity-purified from hybridoma culture supernatant
Immunogen
Human CD34+ bone marrow cells
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated
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Applications
Recommended Concentration
Sample
Flow Cytometry
2.5 µg/106 cells
MG‑63 human osteosarcoma cell line
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
Immunocytochemistry
8-25 µg/mL
See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
Immunocytochemistry
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STRO‑1 in Human MG‑63 Cell Line. STRO-1 was detected in immersion fixed MG-63 human osteosarcoma cell line using Human STRO-1 Monoclonal Antibody (Catalog # MAB1038) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgM Secondary Antibody (red; Catalog # NL019) (Catalog # NL019), and counterstained with DAPI (blue). View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Reconstitution Calculator
Reconstitution Calculator
Preparation and Storage
Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: STRO-1
STRO-1 is a cell surface protein expressed by bone marrow stromal cells and erythroid precursors. The frequency of colony forming units-fibroblasts (CFU-F) was enriched 100-fold in the STRO-1+/Glycophorin A- population from bone marrow cells (1). The subset of marrow cells that expresses the STRO-1 antigen is capable of differentiating into multiple mesenchymal lineages including hematopoiesis-supportive stromal cells with a vascular smooth muscle-like phenotype, adipocytes, osteoblasts, and chondrocytes (2).
Product Datasheets
Citations for Human STRO-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
38
Citations: Showing 1 - 10
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A Clinical Study of Alveolar Bone Tissue Engineering Using Autologous Bone Marrow Stromal Cells: Effect of Optimized Cell-Processing Protocol on Efficacy
Authors: H Kagami, M Inoue, H Agata, I Asahina, T Nagamura-I, M Taguri, A Tojo
Journal of Clinical Medicine, 2022;11(24):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Enamel Matrix Derivative Enhances the Odontoblastic Differentiation of Dental Pulp Stem Cells via Activating MAPK Signaling Pathways
Authors: B Zhang, M Xiao, X Cheng, Y Bai, H Chen, Q Yu, L Qiu
Stem Cells International, 2022;2022(0):2236250.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
A pilot study on biological characteristics of human CD24(+) stem cells from the apical papilla
Authors: J Liang, YJ Zhao, JQ Li, L Lan, WJ Tao, JY Wu
Journal of dental sciences, 2022;17(1):264-275.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Treated dentin matrix induces odontogenic differentiation of dental pulp stem cells via regulation of Wnt/beta-catenin signaling
Authors: S Liu, J Sun, S Yuan, Y Yang, Y Gong, Y Wang, R Guo, X Zhang, Y Liu, H Mi, M Wang, M Liu, R Li
Bioactive materials, 2022;7(0):85-97.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Cellular response of human apical papilla cells to calcium hydroxide and tricalcium silicate-based cements
Authors: M Garrido, D Morales, MP Saldías, C Fernández, V Villalobos, O Cerda, M Cáceres
BMC Oral Health, 2021;21(1):106.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/beta-Catenin Signaling
Authors: Y Gong, S Yuan, J Sun, Y Wang, S Liu, R Guo, W Dong, R Li
Front Physiol, 2020;11(0):918.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
EphrinB2 overexpression enhances osteogenic differentiation of dental pulp stem cells partially through ephrinB2-mediated reverse signaling
Authors: W Wang, C Yuan, T Geng, Y Liu, S Zhu, C Zhang, Z Liu, P Wang
Stem Cell Res Ther, 2020;11(1):40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/&beta-Catenin Signaling
Authors: Y Gong, S Yuan, J Sun, Y Wang, S Liu, R Guo, W Dong, R Li
Front Physiol, 2020;11(0):918.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Fluoxetine induces direct inhibitory effects on mesenchymal stem cell?derived osteoprogenitor cells independent of serotonin concentration
Authors: SM Koura, M Salama, M El-Hussiny, MEA Khalil, A Lotfy, SA Hassan, SA Gad Elhak, MA Sobh
Mol Med Rep, 2019;0(0):.
Species: Rat
Sample Types: Whole Cells
Applications: Flow Cytometry -
Evaluating Interaction of Cord Blood Hematopoietic Stem/Progenitor Cells with Functionally Integrated Three-Dimensional Microenvironments
Authors: S Mokhtari, PM Baptista, DA Vyas, CJ Freeman, E Moran, M Brovold, GA Llamazares, Z Lamar, CD Porada, S Soker, G Almeida-Po
Stem Cells Transl Med, 2018;7(3):271-282.
Species: Human
Sample Types: Whole Cells
Applications: Cell Selection -
Identifying deer antler uhrf1 proliferation and s100a10 mineralization genes using comparative RNA-seq
Authors: DFE Ker, D Wang, R Sharma, B Zhang, B Passarelli, N Neff, C Li, W Maloney, S Quake, YP Yang
Stem Cell Res Ther, 2018;9(1):292.
Species: Deer
Sample Types: Whole Cells
Applications: Flow Cytometry -
Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment
Authors: AJ Villatoro, S Claros, V Fernández, C Alcoholado, F Fariñas, A Moreno, J Becerra, JA Andrades
BMC Vet. Res., 2018;14(1):116.
Species: Feline
Sample Types: Whole Cells
Applications: Flow Cytometry -
Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNF?
Authors: N Sasaki, Y Itakura, M Toyoda
Oncotarget, 2018;9(5):5562-5577.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
In-vitro characterization of canine multipotent stromal cells isolated from synovium, bone marrow, and adipose tissue: a donor-matched comparative study
Authors: RN Bearden, SS Huggins, KJ Cummings, R Smith, CA Gregory, WB Saunders
Stem Cell Res Ther, 2017;8(1):218.
Species: Canine
Sample Types: Whole Cells
Applications: Flow Cytometry -
A monoclonal antibody recognizes undifferentiation-specific carbohydrate moieties expressed on cell surface of the human dental pulp cells
Authors: KJ Kang, SY Ko, CJ Ryu, YJ Jang
Stem Cell Res, 2017;21(0):85-93.
Species: Human
Sample Types: Tissue Homogenates
Applications: Flow Cytometry -
?-Catenin Accumulation Is Associated With Increased Expression of Nanog Protein and Predicts Maintenance of MSC Self-Renewal
Authors: SJ Yu, HJ Kim, ES Lee, CG Park, SJ Cho, SH Jeon
Cell Transplant, 2017;26(2):365-377.
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Human Dental Pulp Cells Differentiate toward Neuronal Cells and Promote Neuroregeneration in Adult Organotypic Hippocampal Slices In Vitro
Authors: L Xiao, R Ide, C Saiki, Y Kumazawa, H Okamura
Int J Mol Sci, 2017;18(8):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70
Stem Cells, 2016;0(0):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Immobilized WNT Proteins Act as a Stem Cell Niche for Tissue Engineering
Stem Cell Reports, 2016;7(1):126-37.
Species: Human
Sample Types: Whole Cells
Applications: IHC -
The differentiation potential of gingival mesenchymal stem cells induced by apical tooth germ cell?conditioned medium
Mol Med Rep, 2016;14(4):3565-72.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HA/Collagen/PLA Scaffold
Authors: X Wang, H Xing, G Zhang, X Wu, X Zou, L Feng, D Wang, M Li, J Zhao, J Du, Y Lv, L E, H Liu
Stem Cells Int, 2016;2016(0):8741641.
Species: Human
Sample Types: Whole Cells
Applications: IHC-Fr -
In vivo experimental model of orthotopic dental pulp regeneration under the influence of photobiomodulation therapy
Authors: Maria Stella Moreira
J. Photochem. Photobiol. B, Biol, 2016;166(0):180-186.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC-P -
Human fetal and adult bone marrow-derived mesenchymal stem cells use different signaling pathways for the initiation of chondrogenesis.
Authors: Brady K, Dickinson S, Guillot P, Polak J, Blom A, Kafienah W, Hollander A
Stem Cells Dev, 2014;23(5):541-54.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Wnts enhance neurotrophin-induced neuronal differentiation in adult bone-marrow-derived mesenchymal stem cells via canonical and noncanonical signaling pathways.
Authors: Tsai H, Deng W, Lai W, Chiu W, Yang C, Tsai Y, Hwang S, Renshaw P
PLoS ONE, 2014;9(8):e104937.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Mesenchymal stem cells engineered to inhibit complement-mediated damage.
Authors: Soland M, Bego M, Colletti E, Zanjani E, St Jeor S, Porada C, Almeida-Porada G
PLoS ONE, 2013;8(3):e60461.
Species: Human
Sample Types: Tissue Homogenates
Applications: Cell Selection -
Intercellular transport of Oct4 in mammalian cells: a basic principle to expand a stem cell niche?
Authors: Rolf HJ, Niebert S, Niebert M, Gaus L, Schliephake H, Wiese KG
PLoS ONE, 2012;7(2):e32287.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
High levels of beta-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway.
Authors: Liu N, Shi S, Deng M, Tang L, Zhang G, Liu N, Ding B, Liu W, Liu Y, Shi H, Liu L, Jin Y
J. Bone Miner. Res., 2011;26(9):2082-95.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Characterization of mesenchymal progenitor cells isolated from human bone marrow by negative selection.
Authors: Modder UI, Roforth MM, Nicks KM, Peterson JM, McCready LK, Monroe DG, Khosla S
Bone, 2011;50(3):804-10.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Synovial sarcoma is a stem cell malignancy.
Authors: Naka N, Takenaka S, Araki N
Stem Cells, 2010;28(7):1119-31.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Stem cells from deciduous tooth repair mandibular defect in swine.
Authors: Zheng Y, Liu Y, Zhang CM
J. Dent. Res., 2009;88(3):249-54.
Species: Porcine
Sample Types: Whole Cells
Applications: ICC -
Three-dimensional reconstituted extracellular matrix scaffolds for tissue engineering.
Authors: Narayanan K, Leck KJ, Gao S, Wan AC
Biomaterials, 2009;30(26):4309-17.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Investigating a clonal human periodontal ligament progenitor/stem cell line in vitro and in vivo.
Authors: Fujii S, Maeda H, Wada N, Tomokiyo A, Saito M, Akamine A
J. Cell. Physiol., 2008;215(3):743-9.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Promotion of attachment of human bone marrow stromal cells by CCN2.
Authors: Ono M, Kubota S, Fujisawa T, Sonoyama W, Kawaki H, Akiyama K, Oshima M, Nishida T, Yoshida Y, Suzuki K, Takigawa M, Kuboki T
Biochem. Biophys. Res. Commun., 2007;357(1):20-5.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage.
Authors: Caddick J, Kingham PJ, Gardiner NJ, Wiberg M, Terenghi G
Glia, 2006;54(8):840-9.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Isolation and characterization of a stem cell population from adult human liver.
Authors: Herrera MB, Bruno S, Buttiglieri S, Tetta C, Gatti S, Deregibus MC, Bussolati B, Camussi G
Stem Cells, 2006;24(12):2840-50.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Mechanical stress promotes the expression of smooth muscle-like properties in marrow stromal cells.
Authors: Kobayashi N, Yasu T, Ueba H, Sata M, Hashimoto S, Kuroki M, Saito M, Kawakami M
Exp. Hematol., 2004;32(12):1238-45.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Multipotent mesenchymal stem cells from human placenta: critical parameters for isolation and maintenance of stemness after isolation.
Authors: Semenov O, Koestenbauer S, Riegel M, Zech N, Zimmermann R, Zisch A, Malek A
Am J Obstet Gynecol, 0;202(2):193.e1-193.e1.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Interferon-gamma improves impaired dentinogenic and immunosuppressive functions of irreversible pulpitis-derived human dental pulp stem cells.
Authors: Sonoda S, Yamaza H, Ma L, Tanaka Y, Tomoda E, Aijima R, Nonaka K, Kukita T, Shi S, Nishimura F, Yamaza T
Sci Rep, 0;6(0):19286.
Species: Human
Sample Types: Whole Tissue
Applications: IHC
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