|Detection of TGF-beta RII in NS0 Mouse Cell Line Transfected with Human TGF-beta RII by Flow Cytometry. NS0 mouse myeloma cell line transfected with human TGF-beta RII was stained with Mouse Anti-Human TGF-beta RII Alexa Fluor® 700-conjugated Monoclonal Antibody (Catalog # FAB241N, filled histogram) or isotype control antibody (Catalog # IC002N, open histogram). View our protocol for Staining Membrane-associated Proteins.|
TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex that transduces TGF-beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the N-terminus of the mature protein has also been described.
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