|Detection of TGF‑ beta RII in NS0 Mouse Cell Line Transfected with Human TGF‑ beta RII by Flow Cytometry. NS0 mouse myeloma cell line transfected with human TGF‑ beta RII was stained with Mouse Anti-Human TGF‑ beta RII Alexa Fluor® 700‑conjugated Monoclonal Antibody (Catalog # FAB241N, filled histogram) or isotype control antibody (Catalog # IC002N, open histogram). View our protocol for Staining Membrane-associated Proteins.|
TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex that transduces TGF-beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the N-terminus of the mature protein has also been described.
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