Show Categories

IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Click on one of the links shown in the Explore Pathways box below to see either the IL-21 signaling pathways or information related to one of the other common cytokine receptor gamma-chain family members.

IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
ProductsClose
CXCR5
CXCR5
ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
ProductsClose
CXCR5
CXCR5
ProductsClose
ProductsClose
CXCR5
CXCR5
ProductsClose
ProductsClose
CXCR5
CXCR5
ProductsClose
Promotes Follicular Helper T Cell Generation
& Germinal Center Formation
Promotes Follicular Helper T Cell Generation
& Germinal Center Formation
ProductsClose
B Cell
B Cell
ProductsClose
Activated
CD4+ T Cell
Activated
CD4+ T Cell
ProductsClose
Developing Germinal Center
Developing Germinal Center
ProductsClose
Centrocyte
Centrocyte
ProductsClose
Tfh Cell
Tfh Cell
ProductsClose
Plasma Cell
Plasma Cell
ProductsClose
Memory B Cell
Memory B Cell
ProductsClose

Follicular Helper T Cell Differentiation

Follicular Helper T Cell Differentiation

ProductsClose
IL-6
IL-6
ProductsClose
IL-6 R
IL-6 R
TGF-beta
TGF-beta
TGF-beta R
TGF-beta R
ProductsClose
STAT3
STAT3
ProductsClose
IL-21
IL-21
ProductsClose
IL-23 R
IL-23 R
ProductsClose
ROR gamma t
ROR gamma t
IL-21
IL-21
ProductsClose
IL-1 beta
IL-1 beta
IL-23
IL-23
IL-21 R
IL-21 R
ProductsClose
STAT3
STAT3
ProductsClose
ROR gamma t
ROR gamma t
IL-17A, F
IL-17A, F
IL-22
IL-22
ProductsClose
Promotes Th17 Differentiation
Promotes Th17 Differentiation
ProductsClose
Dendritic Cell
Dendritic Cell
ProductsClose
Naive T Cell
Naive T Cell
ProductsClose
Differentiating T Cell
Differentiating T Cell
ProductsClose
Th17 Cell
Th17 Cell
ProductsClose

Th17 Differentiation

Th17 Differentiation

ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
IFN-gamma
IFN-gamma
ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
IFN-gamma
IFN-gamma
ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
Granzyme B
Granzyme B
ProductsClose
Enhances Cytotoxicity of CD8+ T Cells,
Natural Killer Cells &
Natural Killer T Cells
Enhances Cytotoxicity of CD8+ T Cells,
Natural Killer Cells &
Natural Killer T Cells
ProductsClose
Activated
CD8+ T Cell
Activated
CD8+ T Cell
ProductsClose
Proliferation
Proliferation
ProductsClose
Perforin Production
Perforin Production
ProductsClose
Natural Killer Cell
Natural Killer Cell
ProductsClose
Perforin Production
Perforin Production
ProductsClose
Granular Morphology
Granular Morphology
ProductsClose
Natural Killer T Cell
Natural Killer T Cell
ProductsClose
Granular Morphology
Granular Morphology
ProductsClose

Increased Cytotoxicity

Increased Cytotoxicity

ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
IL-4 R
IL-4 R
IL-4
IL-4
ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
IL-21 R
IL-21 R
Promotes B Cell Proliferation
& Differentiation
Promotes B Cell Proliferation
& Differentiation
ProductsClose
Antigen
Antigen
ProductsClose
BCR
BCR
ProductsClose
B Cell
B Cell
ProductsClose

Proliferation

Proliferation

ProductsClose

Differentiation

Differentiation

ProductsClose
Plasma Cells
Plasma Cells
ProductsClose
Memory B Cells
Memory B Cells
ProductsClose

B Cell Effects

B Cell Effects

ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
TLR
TLR
Promotes B Cell Apoptosis in the
Absence of BCR & T Cell Signals
Promotes B Cell Apoptosis in the
Absence of BCR & T Cell Signals
ProductsClose
Immature B Cell
Immature B Cell
ProductsClose
TLR Signal
+
No BCR or T Cell
Interaction
Signal
TLR Signal
+
No BCR or T Cell
Interaction
Signal
ProductsClose

Cell Death

Cell Death

ProductsClose

B Cell Apoptosis

B Cell Apoptosis

ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
IL-4
IL-4
ProductsClose
IL-4 R
IL-4 R
Regulates Immunoglobulin Production
& Class Switching
Regulates Immunoglobulin Production
& Class Switching
ProductsClose
Activated B Cell
Activated B Cell
ProductsClose
Plasma Cell
Plasma Cell
ProductsClose

IgG1, IgG2A, IgG2B, IgE
Production

IgG1, IgG2A, IgG2B, IgE
Production

ProductsClose
IL-21
IL-21
ProductsClose
IL-21 R
IL-21 R
Inhibits Dendritic Cell
Maturation & Function
Inhibits Dendritic Cell
Maturation & Function
ProductsClose
Low
Low
ProductsClose
MHC II,
MHC II,
Low
Low
ProductsClose
CCR7
CCR7
ProductsClose
Expression
Expression
ProductsClose
Dendritic Cell
Dendritic Cell
ProductsClose

Antigen-presenting Cell Function

Antigen-presenting Cell Function

ProductsClose
CD4+ or CD8+ T Cells
CD4+ or CD8+ T Cells
ProductsClose

Inhibits T Cell Responses

Inhibits T Cell Responses

ProductsClose
IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Overview of IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types

Interleukin-21 (IL-21) is the most recently described cytokine belonging to the common cytokine receptor gamma-chain family. Like other common gamma chain family members, IL-21 is a four alpha-helix bundle type I cytokine. It signals through a receptor complex consisting of IL-21 R and common gamma-chain/IL-2 R gamma. IL-21 is produced primarily by CD4+ T cells and natural killer T (NKT) cells and has a broad range of effects on a number of different cell types. IL-21 signaling in CD4+ T cells is required for both Th17 differentiation and the generation of T follicular helper (Tfh) cells, which support B cell differentiation and antibody production in germinal centers. IL-21 also directly regulates B cell proliferation and apoptosis in a context-dependent manner and can promote immunoglobulin production and isotype class switching. In addition, IL-21 signaling enhances the cytotoxicity of CD8+ T cells, natural killer cells, and NKT cells.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.

IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types background image 1