IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types

Click on one of the buttons below to see either the IL-4 signaling pathways or information related to one of the other common cytokine receptor gamma-chain family members.

IL-4
IL-4
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IL-4 R
IL-4 R
IL-4 R
IL-4 R
IL-4
IL-4
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TGF-beta R
TGF-beta R
IL-4
IL-4
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TGF-beta
TGF-beta
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STAT6
STAT6
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GATA-3
GATA-3
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IL-4 R
IL-4 R
IL-4 R
IL-4 R
TGF-beta R
TGF-beta R
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IRF4
IRF4
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PU.1/Spi-1
PU.1/Spi-1
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IL-4
IL-4
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IL-4 R
IL-4 R
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IL-4
IL-4
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IL-4 R
IL-4 R
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IL-21
IL-21
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IL-21 R
IL-21 R
IL-4
IL-4
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IL-4 R
IL-4 R
TGF-beta
TGF-beta
TGF-beta R
TGF-beta R
Fc epsilon RI
Fc epsilon RI
IL-4
IL-4
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IL-4 R
IL-4 R
Fc epsilon RI
Fc epsilon RI
IL-4
IL-4
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IL-4 R
IL-4 R
Fc epsilon RI
Fc epsilon RI
VCAM-1
VCAM-1
Regulates Activated
T Cell Proliferation
Regulates Activated
T Cell Proliferation
Activated T Cell
Activated T Cell

Proliferation/Survival

Proliferation/Survival

Promotes Th2 or Th9
Differentiation
Promotes Th2 or Th9
Differentiation
Dendritic Cell
Dendritic Cell
Naive T Cell
Naive T Cell
Th2 Cell
Th2 Cell
Th9 Cell
Th9 Cell

Th2 or Th9 Differentiation

Th2 or Th9 Differentiation

Promotes B Cell
Proliferation
Promotes B Cell
Proliferation
B Cell
B Cell

Proliferation

Proliferation

Regulates Immunoglobulin
Production & Class Switching
Regulates Immunoglobulin
Production & Class Switching
Activated B Cell
Activated B Cell
Plasma Cell
Plasma Cell

IgG1, IgG2A, IgG2B, IgE
Production

IgG1, IgG2A, IgG2B, IgE
Production

Promotes Mast Cell Survival
& Proliferation
Promotes Mast Cell Survival
& Proliferation
Mast Cell
Mast Cell

Apoptosis

Apoptosis

Proliferation/Survival

Proliferation/Survival

Regulates Priming & Chemotaxis
of Mast Cells & Basophils
Regulates Priming & Chemotaxis
of Mast Cells & Basophils
Mast Cell
Mast Cell
Basophil
Basophil

To Inflammation
Site

To Inflammation
Site

Mast Cell & Basophil
Priming/Chemotaxis

Mast Cell & Basophil
Priming/Chemotaxis

Overview of IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types

Interleukin-4 (IL-4) is a glycosylated, type I cytokine with three intra-chain disulfide bridges that adopts a bundled four alpha-helix structure. It is primarily produced by T cells, natural killer T cells, mast cells, and eosinophils. IL-4 initiates signal transduction through one of two different receptor complexes, a type I receptor expressed on hematopoietic cells or a type II receptor expressed on nonhematopoietic cells. The type I receptor consists of the IL-4 R alpha and common gamma-chain/IL-2 R gamma subunits and is specific for IL-4, while the type II receptor consists of the IL-4 R alpha and IL-13 R alpha 1 subunits and can be activated by either IL-4 or IL-13. IL-4 signaling is required for the differentiation of Th2 and Th9 cells and regulates immunoglobulin class switching. In addition, IL-4 plays a central role in the development of allergic inflammation and asthma by enhancing the expression of Fc epsilon RI on B cells, mast cells, and basophils, promoting mast cell survival and proliferation, and inducing mast cell, basophil, and eosinophil chemotaxis.

To learn more, please visit our Common gamma Chain Receptor Family Research Area.