Human TLR10 Alexa Fluor™ Plus 555‑conjugated Antibody

Name: Human TLR10 Alexa Fluor™ Plus 555‑conjugated Antibody
Brand: R&D Systems
SKU: FAB6619AFP555
Price: 549 USD
Availability: InStock

R&D Systems | Catalog # FAB6619AFP555

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Product Documents

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Product Specifications
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Western Blot

Label

Alexa Fluor Plus 555 (Excitation = 558 nm, Emission = 572 nm)

Antibody Source

Monoclonal Mouse IgG_2B Clone # 670719

View all TLR10 Primary Antibodies »

Product Specifications

Specificity

Detects human TLR10 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) TLR1, 2, 3, 4, 5, 7, 8, 9, recombinant mouse (rm) TLR6, 11, 12, rhIL-1 RI, rhIL-1 RII, rhIL-1 RAcP, rhST2, rhIL-18 R, rhIL-1 Rrp2, rhIL-18 R beta, rhSIGIRR, rhIL-1 RAPL1, rhTIGIRR, rhMD-1, rhMD-2, rhTIRAP, or rmRP105 is observed.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG_2B

Applications for Human TLR10 Alexa Fluor™ Plus 555‑conjugated Antibody

Application

Recommended Usage

Western Blot

Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: TLR10

Toll-like receptor 10 (TLR10, CD290) is a 91-100 kDa member of the Toll-like receptor family. Human TLR10 is synthesized as a precursor with a 19 amino acid (aa) signal sequence and a 792 aa mature chain. The mature chain constitutes a single-pass type I transmembrane protein. The extracellular domain (ECD) extends from aa 20-576 and the cytoplasmic region consists of aa 598-811. Human TLR10 contains 15 leucine-rich repeats plus eight potential sites for N-linked glycosylation. In addition, it contains one cytoplasmic TIR domain. Functionally, TLR10 is involved in the innate immune response to microbial agents. Specifically, it acts via MYD88 and TRAF6, which leads to NF-kappa-B activation, cytokine secretion, and an inflammatory response. Human TLR10 shares 71% aa sequence identity with rat TLR10.

Long Name

Toll-like Receptor 10

Alternate Names

CD290

Entrez Gene IDs

81793 (Human)

Gene Symbol

TLR10

UniProt

Q9BXR5

Additional TLR10 Products

Product Documents for Human TLR10 Alexa Fluor™ Plus 555‑conjugated Antibody

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Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human TLR10 Alexa Fluor™ Plus 555‑conjugated Antibody

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

For research use only