Human TRAIL R4/TNFRSF10D Alexa Fluor® 488-conjugated Antibody

  (1 citations)     
Datasheet / CoA / SDS
Product Details
Citations (1)
Supplemental Products
  • Species Reactivity
  • Specificity
    Detects human TRAIL R4/TNFRSF10D in ELISAs and Western blots. In sandwich immunoassays, less than 5% cross-reactivity with recombinant human (rh) TRAIL R1, rhTRAIL R2, rhTRAIL R3, rhTRAIL, rhTNF‑ alpha, and rhTNF-beta is observed.
  • Source
    Monoclonal Mouse IgG1 Clone # 104918
  • Purification
    Protein A or G purified from ascites
  • Immunogen
    Mouse myeloma cell line NS0-derived recombinant human TRAIL R4/TNFRSF10D
    Accession # Q9UBN6
  • Formulation
    Supplied in a saline solution containing BSA and Sodium Azide.
  • Label
    Alexa Fluor 488
Product Datasheets

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  • Flow Cytometry
    5 µL/106 cells
    See below
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Data Example
Detection of TRAIL R4/TNFRSF10D in Human Whole Blood Granulocytes by Flow Cytometry. Human whole blood granulocytes were stained with Mouse Anti-Human TRAIL R4/TNFRSF10D Alexa Fluor® 488‑conjugated Monoclonal Antibody (Catalog # FAB633G, filled histogram) or isotype control antibody (Catalog # IC002G, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
  • Shipping
    The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
  • Stability & Storage
    Protect from light. Do not freeze.
    • 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TRAIL R4/TNFRSF10D
TRAIL-R4, also known as TRAIL-R4 alpha, Decoy Receptor 2 (DcR2) and TNFRSF10D, is a 39-48 kDa member of the TNFR Superfamily of proteins. Mature TRAIL-R4/DcR2 is a type I transmembrane protein 331 amino acids (aa) in length. It contains a 156 aa extracellular domain (ECD) (aa 56-211), and a 154 aa cytoplasmic region that contains a truncated death domain. The presence of this truncation is not believed to allow for a positive signal for the initiation of apoptosis. This has led to its description as a "decoy receptor", suggesting that its function is to simply sequester and decrease the amount of TRAIL available for binding to the two apoptosis-inducing TRAIL receptors, DR4 and DR5. At this time, this view would appear to be unlikely, as it now seems that DcR2 actually complexes with DR5/TRAIL-R2, blocking the activation of Caspase-8, a first step in the initiation of apoptosis. In addition, in a ligand-dependent manner, the presence of DcR2 has also been associated with the increased survival of select leukocytes. Notably, an isoform variant for TRAIL-R4 (called TRAIL-R4 beta ) has been reported that shows an absence of aa 87-124, a deletion that would render it incapable of binding to TRAIL. Cells reported to express TRAIL-R4 are varied, and include eosinophils, NKT cells, CD8+ (but not CD4+) T cells, colonic columnar epithelium, neutrophils, endometrial columnar epithelium, testicular spermatids and testosterone-secreting Leydig cells, and multiple tumor cell types. A rodent counterpart to TRAIL-R4 has not been reported.
  • Long Name:
    TRAIL Receptor 4
  • Entrez Gene IDs:
    8793 (Human)
  • Alternate Names:
    CD264 antigen; CD264; DcR2; DCR2decoy with truncated death domain; Decoy receptor 2; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TNFRSF10D; TRAIL R4; TRAILR4; TRAIL-R4; TRAILR4TRAIL receptor 4; TRUNDDTRAIL receptor with a truncated death domain; tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain
Related Research Areas

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citations: Showing 1 - 1

  1. Dual role of DR5 in death and survival signaling leads to TRAIL resistance in cancer cells
    Authors: Y Shlyakhtin, V Pavet, H Gronemeyer
    Cell Death Dis, 2017;8(8):e3025.
    Species: Human
    Sample Type: Whole Cells
    Application: Flow


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Isotype Controls
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Mouse IgG1 Alexa Fluor® 488-conjugated Antibody

Ctrl IC002G 4  
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Staining Reagents
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Flow Cytometry Staining Buffer (1X)

Flow FC001 7
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Flow Cytometry Mouse Lyse Buffer (10X)

Flow FC003 5
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Flow Cytometry Human Lyse Buffer (10X)

Flow FC002 1
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